Trigeminal Neuralgia
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Management of Primary Bilateral Trigeminal Neuralgia with Microvascular Decompression: 13-Case Series.
Authors:Zhao H, Wang XH, Zhang Y, Zhang X, Tang YD, Zhou P, Zhu J, Li ST
Institution:Department of Neurosurgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:; Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal:World Neurosurg. 2018 Jan;109:e724-e730. doi: 10.1016/j.wneu.2017.10.072. Epub 2017 Oct 21.

2:Outcomes of Two-Isocenter Gamma Knife Radiosurgery for Patients with Typical Trigeminal Neuralgia: Pain Response and Quality of Life.
Authors:Zhao H, Shen Y, Yao D, Xiong N, Abdelmaksoud A, Wang H
Institution:Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Huazhong, Hubei Province, China. Electronic address:
Journal:World Neurosurg. 2018 Jan;109:e531-e538. doi: 10.1016/j.wneu.2017.10.014. Epub 2017 Oct 13.

3:Long-Term Efficacy of Nerve Combing for Patients with Trigeminal Neuralgia and Failed Prior Microvascular Decompression.
Authors:Zhang X, Xu L, Zhao H, Tang YD, Zhu J, Yuan Y, Zhou P, Li ST
Institution:Department of Neurosurgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Center for Diagnosis and Treatment of Cranial Nerve Diseases, Shanghai Jiao Tong University, Shanghai, China. Electronic address:; Department of Neurosurgery, Affiliated Hospital of Zunyi Medical College, Guizhou, China.
Journal:World Neurosurg. 2017 Dec;108:711-715. doi: 10.1016/j.wneu.2017.09.081. Epub 2017 Sep 21.

4:Stereotactic Radiosurgery for Type 1 versus Type 2 Trigeminal Neuralgias.
Authors:Chen CJ, Paisan G, Buell TJ, Knapp K, Ding D, Xu Z, Raper DM, Taylor DG, Dallapiazza RF, Lee CC, Sheehan JP
Institution:Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia, USA. Electronic address: Charlottesville, Virginia, USA. Charlottesville, Virginia, USA. Charlottesville, Virginia, USA. Charlottesville, Virginia, USA. Charlottesville, Virginia, USA. Charlottesville, Virginia, USA. Hospital, Taipei, Taiwan. Charlottesville, Virginia, USA.
Journal:World Neurosurg. 2017 Dec;108:581-588. doi: 10.1016/j.wneu.2017.09.055. Epub 2017 Sep 18.

5:Factors Determining the Outcome in Trigeminal Neuralgia Treated With Percutaneous Balloon Compression.
Authors:Unal TC, Unal OF, Barlas O, Hepgul K, Ali A, Aydoseli A, Aras Y, Sabanci PA, Sencer A, Izgi N
Institution:Department of Neurosurgery, Tunceli State Hospital, Tunceli, Turkey. Electronic address: Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey. Istanbul, Turkey.
Journal:World Neurosurg. 2017 Nov;107:69-74. doi: 10.1016/j.wneu.2017.07.132. Epub 2017 Jul 30.

6:Microvascular Decompression for Trigeminal Neuralgia Using a Novel Fenestrated Clip and Tentorial Flap Technique.
Authors:Gonzalez-Quarante LH, Ruiz-Juretschke F, Agarwal V, Garcia-Leal R
Institution:Department of Neurosurgery, Hospital Universitario HM Sanchinarro, Madrid, Spain; Department of Neurosurgery, Hospital General Universitario Gregorio Maranon, Madrid, Spain. Electronic address: Madrid, Spain. Madrid, Spain.
Journal:World Neurosurg. 2017 Oct;106:775-784. doi: 10.1016/j.wneu.2017.07.110. Epub 2017 Jul 25.

7:Symptomatic Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors.
Authors:Liu P, Liao C, Zhong W, Yang M, Li S, Zhang W
Institution:Department of Neurosurgery, XinHua Hospital, Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.
Journal:J Craniofac Surg. 2017 May;28(3):e256-e258. doi: 10.1097/SCS.0000000000003481.

8:Meta-Analysis on Safety and Efficacy of Microsurgical and Radiosurgical Treatment of Trigeminal Neuralgia.
Authors:Gubian A, Rosahl SK
Institution:Department of Neurosurgery, HELIOS Klinikum Erfurt, Erfurt, Germany. Electronic address:
Journal:World Neurosurg. 2017 Jul;103:757-767. doi: 10.1016/j.wneu.2017.04.085. Epub 2017 Apr 20.

9:Trigeminal Neuralgia: Toward a Multimodal Approach.
Authors:Spina A, Mortini P, Alemanno F, Houdayer E, Iannaccone S
Institution:Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy. Electronic address:; Department of Clinical Neuroscience, Specialistic Neurorehabilitation of Neurological, Cognitive and Motor Disorders, San Raffaele Scientific Institute, Milan, Italy.
Journal:World Neurosurg. 2017 Jul;103:220-230. doi: 10.1016/j.wneu.2017.03.126. Epub 2017 Apr 2.

10:Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia.
Authors:Sandrini G, De Icco R, Tassorelli C, Smania N, Tamburin S
Institution:C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy. Verona, Piazzale Scuro 10, I-37134, Verona, Italy. Verona, Italy.
Journal:J Headache Pain. 2017 Dec;18(1):38. doi: 10.1186/s10194-017-0744-z. Epub 2017 Mar 21.

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