Trigeminal Neuralgia
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Trigeminal Neuralgia abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Trigeminal Neuralgia. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Trigeminal Neuralgia. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Trigeminal Neuralgia every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Long-term outcome of percutaneous balloon compression for trigeminal neuralgia patients elder than 80 years: A STROBE-compliant article.
Authors:Ying X, Wang H, Deng S, Chen Y, Zhang J, Yu W
Institution:aDepartment of Neurosurgery, Hangzhou First People's Hospital, Zhejiang Chinese Medical University bDepartment of Neurosurgery, Hangzhou First People's Hospital, Nanjing Medical University cDepartment of Anesthesia and Pain Medicine, Tonglu First People's Hospital, Hangzhou, Zhejiang, P.R. China.
Journal:Medicine (Baltimore). 2017 Sep;96(39):e8199. doi: 10.1097/MD.0000000000008199.

2:Botulinum toxin in the treatment of trigeminal neuralgia: 6-Month follow-up.
Authors:Turk Boru U, Duman A, Boluk C, Coskun Duman S, Tasdemir M
Institution:aDepartment of Neurology, Dr. Lutfi Kirdar Kartal Training and Research Hospital bDepartment of Neurology, Maltepe State Hospital cDepartment of Public Health, Bezmialem University, Istanbul, Turkey.
Journal:Medicine (Baltimore). 2017 Sep;96(39):e8133. doi: 10.1097/MD.0000000000008133.

3:Meta-Analysis on Safety and Efficacy of Microsurgical and Radiosurgical Treatment of Trigeminal Neuralgia.
Authors:Gubian A, Rosahl SK
Institution:Department of Neurosurgery, HELIOS Klinikum Erfurt, Erfurt, Germany. Electronic address:
Journal:World Neurosurg. 2017 Jul;103:757-767. doi: 10.1016/j.wneu.2017.04.085. Epub 2017 Apr 20.

4:Trigeminal Neuralgia: Toward a Multimodal Approach.
Authors:Spina A, Mortini P, Alemanno F, Houdayer E, Iannaccone S
Institution:Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy. Electronic address:; Department of Clinical Neuroscience, Specialistic Neurorehabilitation of Neurological, Cognitive and Motor Disorders, San Raffaele Scientific Institute, Milan, Italy.
Journal:World Neurosurg. 2017 Jul;103:220-230. doi: 10.1016/j.wneu.2017.03.126. Epub 2017 Apr 2.

5:Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia.
Authors:Sandrini G, De Icco R, Tassorelli C, Smania N, Tamburin S
Institution:C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy. Verona, Piazzale Scuro 10, I-37134, Verona, Italy. Verona, Italy.
Journal:J Headache Pain. 2017 Dec;18(1):38. doi: 10.1186/s10194-017-0744-z. Epub 2017 Mar 21.

6:Safety and efficacy of a Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia: a double-blind, placebo-controlled, randomised withdrawal phase 2a trial.
Authors:Zakrzewska JM, Palmer J, Morisset V, Giblin GM, Obermann M, Ettlin DA, Cruccu G, Bendtsen L, Estacion M, Derjean D, Waxman SG, Layton G, Gunn K, Tate S
Institution:Facial Pain Unit, Division of Diagnostic, Surgical and Medical Sciences, Eastman Dental Hospital, University College London Hospitals NHS Foundation Trust/University College London, London, UK. Electronic address: Essen, Germany; Center for Neurology, Asklepios Hospitals Schildautal, Seesen, Germany. University of Zurich, Zurich, Switzerland. University of Copenhagen, Nordre Ringvej 67, 2600 Glostrup, Denmark. Yale University School of Medicine, and Veterans Affairs Medical Center, West Haven, CT, USA. Yale University School of Medicine, and Veterans Affairs Medical Center, West Haven, CT, USA.
Journal:Lancet Neurol. 2017 Apr;16(4):291-300. doi: 10.1016/S1474-4422(17)30005-4. Epub 2017 Feb 17.

7:Trigeminal nerve block with alcohol for medically intractable classic trigeminal neuralgia: long-term clinical effectiveness on pain.
Authors:Han KR, Chae YJ, Lee JD, Kim C
Institution:Kichan Pain Clinic, Suwon, Korea.
Journal:Int J Med Sci. 2017 Jan 1;14(1):29-36. doi: 10.7150/ijms.16964. eCollection 2017.

8:Is There a Magnetic Resonance Imaging-Discernible Cause for Trigeminal Neuralgia? A Structured Review.
Authors:Alper J, Shrivastava RK, Balchandani P
Institution:Icahn School of Medicine at Mount Sinai, The Translational and Molecular Imaging Institute, New York, New York, USA; Grove School of Engineering, Department of Biomedical Engineering, City College of New York, New York, New York, USA. Electronic address: Institute, New York, New York, USA.
Journal:World Neurosurg. 2017 Feb;98:89-97. doi: 10.1016/j.wneu.2016.10.104. Epub 2016 Oct 27.

9:Comparison of Percutaneous Retrogasserian Balloon Compression and Gamma Knife Radiosurgery for the Treatment of Trigeminal Neuralgia in Multiple Sclerosis.
Authors:Alvarez-Pinzon AM, Wolf AL, Swedberg HN, Barkley KA, Cucalon J, Curia L, Valerio JE
Institution:Department of Neurological Surgery, Miami Neuroscience Center at Larkin, South Miami, Florida, USA; Biotechnology-Oncology, Advanced Academic Programs, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: Miami, Florida, USA. USA. USA. Miami, Florida, USA.
Journal:World Neurosurg. 2017 Jan;97:590-594. doi: 10.1016/j.wneu.2016.10.028. Epub 2016 Oct 15.

10:Pulsed Radiofrequency: A Management Option for Recurrent Trigeminal Neuralgia Following Radiofrequency Thermocoagulation.
Authors:Liao C, Visocchi M, Yang M, Liu P, Li S, Zhang W
Institution:Department of Neurosurgery, XinHua Hospital affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China. Electronic address:; Department of Neurosurgery, Catholic University School of Medicine, Largo A. Gemelli, Rome, Italy.
Journal:World Neurosurg. 2017 Jan;97:760.e5-760.e7. doi: 10.1016/j.wneu.2016.09.108. Epub 2016 Oct 10.

11:Outcome of radiosurgery treatment with a linear accelerator in patients with trigeminal neuralgia.
Authors:Cordero Tous N, Cruz Sabido J, Roman Cutillas AM, Saura Rojas EJ, Jorques Infante AM, Olivares Granados G
Institution:Servicio de Neurocirugia, Complejo Hospitalario de Jaen, Hospital Neurotraumatologico, Jaen, Espana. Electronic address:; Servicio de Neurocirugia, Hospital Universitario Virgen de las Nieves, Hospital de Rehabilitacion y Traumatologia, Granada, Espana.
Journal:Neurologia. 2017 Apr;32(3):166-174. doi: 10.1016/j.nrl.2015.10.003. Epub 2015 Dec 14.

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