Peripheral Neuropathy
December 2017 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Peripheral Neuropathy abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Peripheral Neuropathy. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Peripheral Neuropathy. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Peripheral Neuropathy every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Dose-response of pregabalin for diabetic peripheral neuropathy, postherpetic neuralgia, and fibromyalgia.
Authors:Arnold LM, McCarberg BH, Clair AG, Whalen E, Thomas N, Jorga A, Pauer L, Vissing R, Park PW
Institution:a Department of Psychiatry and Behavioral Neuroscience, Women's Health Research Program , University of Cincinnati College of Medicine , Cincinnati , OH , USA. Medicine , San Diego , CA , USA. CT , USA.
Journal:Postgrad Med. 2017 Nov;129(8):921-933. doi: 10.1080/00325481.2017.1384691. Epub 2017 Oct 16.

2:Risk-reduction and treatment of chemotherapy-induced peripheral neuropathy.
Authors:Bakogeorgos M, Georgoulias V
Institution:a Department of Medical Oncology , Athens , Greece.
Journal:Expert Rev Anticancer Ther. 2017 Nov;17(11):1045-1060. doi: 10.1080/14737140.2017.1374856. Epub 2017 Sep 11.

3:Yang-warming method in the treatment of diabetic peripheral neuropathy: an updated systematic review and meta-analysis.
Authors:Panthi S, Jing X, Gao C, Gao T
Institution:Department of Chronic Disease, Liaoning University of Traditional Chinese Medicine, Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
Journal:BMC Complement Altern Med. 2017 Aug 25;17(1):424. doi: 10.1186/s12906-017-1927-5.

4:Intravenous immunoglobulin for maintenance treatment of chronic inflammatory demyelinating polyneuropathy: a multicentre, open-label, 52-week phase III trial.
Authors:Kuwabara S, Mori M, Misawa S, Suzuki M, Nishiyama K, Mutoh T, Doi S, Kokubun N, Kamijo M, Yoshikawa H, Abe K, Nishida Y, Okada K, Sekiguchi K, Sakamoto K, Kusunoki S, Sobue G, Kaji R
Institution:Department of Neurology, Chiba University Hospital, Chiba, Japan. Japan. Japan. Sapporo, Japan. Medicine, Nishinomiya, Japan. School of Medicine, Kitakyushu, Japan. Japan.
Journal:J Neurol Neurosurg Psychiatry. 2017 Oct;88(10):832-838. doi: 10.1136/jnnp-2017-316427. Epub 2017 Aug 2.

5:Chemotherapy-induced peripheral neuropathy clinical trials: Review and recommendations.
Authors:Gewandter JS, Freeman R, Kitt RA, Cavaletti G, Gauthier LR, McDermott MP, Mohile NA, Mohlie SG, Smith AG, Tejani MA, Turk DC, Dworkin RH
Institution:From the Departments of Anesthesiology (J.S.G., R.A.K., R.H.D.), Biostatistics and Computational Biology (M.P.M.), Neurology (N.A.M., M.A.T.), and Medicine, Hematology/Oncology (S.G.M.), University of Rochester, NY; Department of Neurology (R.F.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Experimental Neurology Unit (G.C.), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy; Department of Family Medicine and Emergency Medicine (L.R.G.), Faculty of Medicine, Universite Laval, Quebec, Canada; Department of Neurology (A.G.S.), University of Utah, Salt Lake City; and Department of Anesthesiology and Pain Medicine (D.C.T.), University of Washington, Seattle.
Journal:Neurology. 2017 Aug 22;89(8):859-869. doi: 10.1212/WNL.0000000000004272. Epub 2017 Jul 26.

6:Interventions for Neuropathic Pain: An Overview of Systematic Reviews.
Authors:Dosenovic S, Jelicic Kadic A, Miljanovic M, Biocic M, Boric K, Cavar M, Markovina N, Vucic K, Puljak L
Institution:From the Departments of *Anesthesiology and Intensive Care and daggerPediatrics, University Hospital Center Split, Split, Croatia; double daggerAgency for Quality and Accreditation in Health Care and Social Welfare, Zagreb, Croatia; section signLaboratory for Pain Research, Department of Anatomy, Histology and Embryology, University of Split School of Medicine, Split, Croatia; parallelDepartment of Radiology, University Hospital Center Split, Split, Croatia; and paragraph signAgency for Medicinal Products and Medical Devices, Zagreb, Croatia.
Journal:Anesth Analg. 2017 Aug;125(2):643-652. doi: 10.1213/ANE.0000000000001998.

7:Drug therapy for chronic idiopathic axonal polyneuropathy.
Authors:Warendorf J, Vrancken AF, van Schaik IN, Hughes RA, Notermans NC
Institution:Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584 CX.
Journal:Cochrane Database Syst Rev. 2017 Jun 20;6:CD003456. doi: 10.1002/14651858.CD003456.pub3.

8:Aromatherapy Massage for Neuropathic Pain and Quality of Life in Diabetic Patients.
Authors:Gok Metin Z, Arikan Donmez A, Izgu N, Ozdemir L, Arslan IE
Institution:Research Assistant, Hacettepe University Faculty of Nursing, Internal Medicine Nursing Department, Ankara, Turkey. Nursing Department, Ankara, Turkey. Nursing Department, Ankara, Turkey. Nursing Department, Ankara, Turkey. Ankara, Turkey.
Journal:J Nurs Scholarsh. 2017 Jul;49(4):379-388. doi: 10.1111/jnu.12300. Epub 2017 Jun 12.

9:Declining Skeletal Muscle Function in Diabetic Peripheral Neuropathy.
Authors:Parasoglou P, Rao S, Slade JM
Institution:Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York; Center for Advanced Imaging Innovation and Research (CAI(2)R), Department of Radiology, New York University School of Medicine, New York, New York. Electronic address: Biomedical Imaging Research Center, Michigan State University, East Lansing, Michigan.
Journal:Clin Ther. 2017 Jun;39(6):1085-1103. doi: 10.1016/j.clinthera.2017.05.001. Epub 2017 May 30.

10:Polyneuropathy relates to impairment in daily activities, worse gait, and fall-related injuries.
Authors:Hanewinckel R, Drenthen J, Verlinden VJA, Darweesh SKL, van der Geest JN, Hofman A, van Doorn PA, Ikram MA
Institution:From the Departments of Epidemiology (R.H., V.J.A.V., S.K.L.D., A.H., M.A.I.), Neurology (R.H., J.D., P.A.v.D.), Neuroscience (J.D., J.N.v.d.G.), and Clinical Neurophysiology (J.D.), Erasmus University Medical Center, Rotterdam, the Netherlands; and Department of Epidemiology (S.K.L.D., A.H.), Harvard T.H. Chan School of Public Health, Boston, MA.
Journal:Neurology. 2017 Jul 4;89(1):76-83. doi: 10.1212/WNL.0000000000004067. Epub 2017 May 31.

11:Advances in the management of diabetic neuropathy.
Authors:Varkonyi T, Korei A, Putz Z, Martos T, Keresztes K, Lengyel C, Nyiraty S, Stirban A, Jermendy G, Kempler P
Institution:First Department of Medicine, University of Szeged, Szeged, Hungary - Hungary. Hungary.
Journal:Minerva Med. 2017 Oct;108(5):419-437. doi: 10.23736/S0026-4806.17.05257-0. Epub 2017 May 25.

12:Association of Long-term Opioid Therapy With Functional Status, Adverse Outcomes, and Mortality Among Patients With Polyneuropathy.
Authors:Hoffman EM, Watson JC, St Sauver J, Staff NP, Klein CJ
Institution:Department of Neurology, Mayo Clinic, Rochester, Minnesota. Medicine, Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Journal:JAMA Neurol. 2017 Jul 1;74(7):773-779. doi: 10.1001/jamaneurol.2017.0486.

13:Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.
Authors:Lewis EJH, Perkins BA, Lovblom LE, Bazinet RP, Wolever TMS, Bril V
Institution:From the Department of Nutritional Sciences (E.J.H.L., R.P.B., T.M.S.W.), Faculty of Medicine, University of Toronto; Leadership Sinai Centre for Diabetes (B.A.P., L.E.L.), Mount Sinai Hospital, Toronto; and Ellen and Martin Prosserman Centre for Neuromuscular Diseases (V.B.), Division of Neurology, University Health Network, Toronto, Canada.
Journal:Neurology. 2017 Jun 13;88(24):2294-2301. doi: 10.1212/WNL.0000000000004033. Epub 2017 May 17.

14:Chemotherapy-induced peripheral neuropathy: A current review.
Authors:Staff NP, Grisold A, Grisold W, Windebank AJ
Institution:Department of Neurology, Mayo Clinic, Rochester, MN. Austria.
Journal:Ann Neurol. 2017 Jun;81(6):772-781. doi: 10.1002/ana.24951. Epub 2017 Jun 5.

15:Update on Chemotherapy-Induced Peripheral Neuropathy.
Authors:Cioroiu C, Weimer LH
Institution:Neurological Institute of New York, Columbia University Medical Center, 710 W168th Street, New York, NY, 10032, USA. W168th Street, New York, NY, 10032, USA.
Journal:Curr Neurol Neurosci Rep. 2017 Jun;17(6):47. doi: 10.1007/s11910-017-0757-7.

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