Meniere's Disease
December 2022 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Meniere's Disease abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Meniere's Disease. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Meniere's Disease. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Meniere's Disease every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Assessment of inner ear morphology and function in response to local positive pressure for Ménière's disease: a nonrandomized controlled trial.
Authors:Fukushima M, Akahani S, Okamoto H, Takeda N, Inohara H
Institution:Department of Otolaryngology and Head and Neck Surgery, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan.; Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Journal:Sci Rep. 2022 Dec 1;12(1):20782. doi: 10.1038/s41598-022-25321-z.

2:Association between Osteoporosis and Meniere's Disease: Two Longitudinal Follow-Up Cohort Studies.
Authors:Choi HG, Chung J, Yoo DM, Lee CH, Kim SY
Institution:Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Republic of Korea.; Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Republic of Korea.
Journal:Nutrients. 2022 Nov 18;14(22):4885. doi: 10.3390/nu14224885.

3:Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease.
Authors:Kashizadeh A, Pastras C, Rabiee N, Mohseni-Dargah M, Mukherjee P, Asadnia M
Institution:School of Electrical and Computer Engineering, Shahid Beheshti University, Tehran 1983969411, Iran.; School of Engineering, Macquarie University, Sydney, NSW 2109, Australia. Electronic address:
Journal:Nanomedicine. 2022 Nov;46:102599. doi: 10.1016/j.nano.2022.102599. Epub 2022 Sep 5.

4:Cochlear implant outcomes in patients with Meniere's disease: a large case series.
Authors:Kanona H, Forde C, Van Rooyen AM, Keating P, Bradley J, Pendolino AL, Mehta N, Manjaly JG, Khalil S, Lavy J, Saeed SR, Shaida A
Institution:The Royal National Ear Nose and Throat Hospital and Eastman Dental Hospital, University College Hospitals, London, UK.
Journal:Cochlear Implants Int. 2022 Nov;23(6):339-346. doi: 10.1080/14670100.2022.2112998. Epub 2022 Sep 1.

5:Prevalence of anxiety and depression in Meniere's disease; a comparative analytical study.
Authors:Lahiji MR, Akbarpour M, Soleimani R, Asli RH, Leyli EK, Saberi A, Akbari M, Ramezani H, Nemati S
Institution:Otorhinolaryngology Research Center, Department of Otolaryngology and Head &Neck Surgery, School of Medicine, Guilan University of Medical Sciences, Amir Al-Momenin Hospital, Rasht, Iran. Electronic address:
Journal:Am J Otolaryngol. 2022 Sep-Oct;43(5):103565. doi: 10.1016/j.amjoto.2022.103565. Epub 2022 Aug 2.

6:Treatment of Meniere's disease by Multi-session Dexamethasone Injections.
Authors:Alsarhan H, Kadhim S
Institution:Department of Surgery - College of Medicine/Mustansiriyah University - Baghdad - Iraq.; Alnukhba University College - Baghdad - Iraq.
Journal:Int Tinnitus J. 2022 Jun 21;26(1):75-78. doi: 10.5935/0946-5448.20220011.

7:Surgical Management of Intractable Meniere's Disease.
Authors:Luca P, Ralli M, Cassandro C, Russo FY, Gioacchini FM, Cavaliere M, Fiore M, Greco A, Cassandro E, Scarpa A
Institution:Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
Journal:Int Tinnitus J. 2022 Jun 21;26(1):50-56. doi: 10.5935/0946-5448.20220007.

8:Risk factors for Meniere disease: a systematic review and meta-analysis.
Authors:Hu C, Yang W, Kong W, Fan J, He G, Zheng Y, Ren J, Dong C
Institution:Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, China.
Journal:Eur Arch Otorhinolaryngol. 2022 Dec;279(12):5485-5496. doi: 10.1007/s00405-022-07505-5. Epub 2022 Jul 6.

9:Population-based study for the comorbidities and associated factors in Ménière's disease.
Authors:Kim MH
Institution:Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Kyung Hee University Hospital at Gangdong, Dongnam-ro 892, Seoul, 05278, Republic of Korea.
Journal:Sci Rep. 2022 May 18;12(1):8266. doi: 10.1038/s41598-022-12492-y.

10:Endolymphatic hydrops in the unaffected ear of patients with unilateral Ménière's disease.
Authors:Guajardo-Vergara C, Suárez-Vega V, Dominguez P, Manrique-Huarte R, Arbizu L, Pérez-Fernández N
Institution:Department of Otorhinolaryngology, Clinica Universidad de Navarra, Pamplona, Spain.
Journal:Eur Arch Otorhinolaryngol. 2022 Dec;279(12):5591-5600. doi: 10.1007/s00405-022-07412-9. Epub 2022 May 16.

11:Consensus on intratympanic drug delivery for Menière's disease.
Authors:Li S, Pyykkö I, Zhang Q, Yang J, Duan M
Institution:Department of Otorhinolaryngology-Head & Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.; Department of Otolaryngology-Head & Neck, Audiology and Neurotology, Karolinska University Hospital, Stockholm, Sweden.
Journal:Eur Arch Otorhinolaryngol. 2022 Aug;279(8):3795-3799. doi: 10.1007/s00405-022-07374-y. Epub 2022 Apr 26.

12:Duration of symptom control following intratympanic dexamethasone injections in Meniere's disease.
Authors:Hilton A, McClelland A, McCallum R, Kontorinis G
Institution:Faculty of Medicine, University of Glasgow, Glasgow, UK.
Journal:Eur Arch Otorhinolaryngol. 2022 Nov;279(11):5191-5198. doi: 10.1007/s00405-022-07368-w. Epub 2022 Apr 10.

13:Association Between Meniere Disease and Migraine.
Authors:Kim SY, Lee CH, Yoo DM, Kwon MJ, Kim JH, Kim JH, Park B, Lee HJ, Choi HG
Institution:Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea.; Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.
Journal:JAMA Otolaryngol Head Neck Surg. 2022 May 1;148(5):457-464. doi: 10.1001/jamaoto.2022.0331.

14:Interventions for Menière's disease: an umbrella systematic review.
Authors:van Esch BF, van der Zaag-Loonen H, Bruintjes T, Kuijpers T, van Benthem PPG
Institution:Apeldoorn Dizziness Centre, Gelre Ziekenhuizen, Apeldoorn, The Netherlands; Otorhinolaryngology - Head and Neck Surgery, Leiden University Medical Center, Leiden, Zuid-Holland, The Netherlands.
Journal:BMJ Evid Based Med. 2022 Aug;27(4):235-245. doi: 10.1136/bmjebm-2020-111410. Epub 2021 Nov 8.

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